Cost-Effectiveness Analysis of Using Factor VII + Von Willebrand Factor In Treatment of Patients with Von Willebrand Disease
نویسندگان
چکیده
منابع مشابه
Treatment of patients with von Willebrand disease
Von Willebrand disease (vWD) is the most common hereditary bleeding disorder. The aim of therapy is to correct the dual hemostatic defect, due to defective platelet adhesion-aggregation and abnormal coagulation due to Factor VIII (FVIII) deficiency. The choice of treatment depends on a number of factors, including the severity of the bleed, the procedure planned, the subtype and severity of the...
متن کاملZebrafish von Willebrand factor.
von Willebrand factor (vWF) is a large protein involved in primary hemostasis. A dysfunction in this protein or an insufficient production of the protein leads to improper platelet adhesion/aggregation, resulting in a bleeding phenotype known as von Willebrand disease (vWD). To gain a better understanding of vWF interactions in vivo, the use of zebrafish as a model is ideal because of the trans...
متن کاملHuman von Willebrand factor/factor VIII concentrates in the management of pediatric patients with von Willebrand disease/hemophilia A
Several plasma-derived intermediate and high-purity concentrates containing von Willebrand factor (VWF) and factor VIII (FVIII) are currently available. The main role of these products in the management of the pediatric population is represented by the replacement therapy in patients with severe or intermediate forms of von Willebrand disease, in whom other treatments are ineffective or contrai...
متن کاملGenetic Variation in the von Willebrand Factor Gene in Swedish von Willebrand Disease Patients
von Willebrand disease (VWD) is often caused by genetic defects in the vonWillebrand factor (VWF) gene and is divided into three major subtypes: type 3 (VWD3) is characterized by total absenceofVWF, type2 (VWD2)by functionaldisturbance of VWF, and type 1 (VWD1) by low plasma concentration of functionally normal VWF.1 Diagnosis of VWD is challenging due to theheterogeneity of the disease and can...
متن کاملVon Willebrand factor.
The adhesive protein von Willebrand factor contributes to platelet function by mediating the initiation and progression of thrombus formation at sites of vascular injury. In the last 2 years, there has been considerable progress in explaining the biologic properties of von Willebrand factor. The three-dimensional structure of specific domains has been explained, with the demonstration of distin...
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ژورنال
عنوان ژورنال: Value in Health
سال: 2016
ISSN: 1098-3015
DOI: 10.1016/j.jval.2016.09.1392